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Genetics Laboratory
The genetic laboratory is an assessment requirement for third-generation test tube qualification applications, and the laboratory needs to be equipped with high-throughput sequencers, automated workstations, PCR analyzers, PGT and genetic testing reagent kits, etc. Large-scale clinical trials show that PGT-A can increase the clinical pregnancy rate to 72%, and reduce the miscarriage rate to 6.9%. Basecare Medical participated in the drafting of quality control technical evaluation guidelines for PGT-A detection reagents, and the developed PGT-A reagent kit obtained the first 'Special Approval for Innovative Medical Devices' for Class III medical devices, filling the clinical gap of genetic testing reagent kits for third-generation test tube babies in China. PGT-M and PGT-SR reagent kits can be used to block the transmission of genetic diseases to the next generation. In addition, Basecare Medical's domestically produced high-throughput sequencer DA500 has obtained the national Class III medical device registration certificate.


Main Equipment
DA8600 Gene Sequencer
The DA8600 semiconductor gene sequencer is a new generation high-throughput sequencer developed and produced by Sun Yat-sen University Da An Gene Co., Ltd., specifically for clinical applications. It is also the first domestically approved medical device registration certificate issued by the National Medical Products Administration, Registration No. 20143221961.of the semiconductor gene sequencer. Currently, Basecare Medical has obtained the exclusive authorization for the DA8600 semiconductor gene sequencer in the field of assisted reproduction, and is fully responsible for the sales and after-sales service of the equipment in the field of assisted reproduction.language_492
- Fast SpeedCompletes a genetic test in just 2-3 hours, significantly improving detection efficiency
- Long Sequencing ReadsAverage sequencing read length of 200bp ensures data accuracy and reliability
- Moderate ThroughputCan simultaneously sequence multiple projects, balancing clinical testing costs and reporting cycles
- Widespread ApplicationApproved for Class III reagent kits in non-invasive prenatal, tumor, and reproductive fields

DA500 High-Throughput Sequencer
DA500 High-Throughput Sequencer (National Medical Device Registration 20233221281) is a compact, flexible desktop single-slide gene sequencing platform that provides users with flexible and efficient sequencing choices. The sequencer adopts excellent biochemical and optical systems, supports two different chip specifications, and can generate sequencing data volumes ranging from 10Gb to 150Gb in a single run. It also has stable high-intensity signals and a low sequencing error rate, meeting the needs of customers for sequencing throughput and efficiency in different scenarios.
- Flexible Sequencing ThroughputSupports two different chip specifications, with sequencing data volumes ranging from 10Gb to 150Gb
- High AccuracyUses rolling circle replication amplification technology and carries a regular array slide to improve sequencing accuracy
- High Compatibility with Detection ProjectsApplicable to pre-pregnancy, prenatal, pre-implantation, and newborn screening throughout the entire reproductive cycle
- Low Operating CostsCan meet the requirements for sequencing throughput and efficiency in different scenarios

BS1000C Automated Sample Preparation System
The BS1000C high-throughput automated sample preparation system is a compact, feature-rich, and flexible desktop multifunctional automated workstation. It can help you automate most library construction processes. The workstation is equipped with a 96-channel pipettor, built-in routine high-throughput sequencing library construction processes, and nucleic acid extraction processes. It is designed for fully automated operations and can achieve long periods of unattended operation. It can also be customized according to customer needs, making it an efficient, flexible, and widely applicable automated sample preparation system.
- Fully AutomatedIntegrates multiple instruments and equipment for fully automated library construction and other experimental operations
- Flexible and ReliableSwitch between 8 to 96 channels flexibly, with 20 modules in various combinations, customizable based on requirements
- Easy OperationAutomated library construction with graphical user guidance, intuitive and quick to operate, less prone to errors
- Safe and StableEquipped with UV lamp and efficient filter, reduces aerosol contamination risk, ensuring personnel safety


Main Reagents
Pre-Implantation Chromosome Aneuploidy Detection Reagent Kit (Semiconductor Sequencing Method)
Basecare Medical's production of the 'Pre-Implantation Chromosome Aneuploidy Detection Reagent Kit (Semiconductor Sequencing Method)' is the first PGT-A detection reagent kit approved for marketing by the National Medical Products Administration (NMPA) in China (National Medical Device Registration 20203400181). The reagent kit is based on high-throughput sequencing technology, qualitatively detecting the DNA of embryonic trophectoderm cells during the in vitro fertilization process, analyzing whether the embryo's chromosomes have aneuploidy abnormalities, and assisting clinical doctors in determining whether the embryo is suitable for implantation.
National Certification
- language_523High Precision
- Covers a Wide RangeDetects chromosomal aneuploidy with a sensitivity, specificity, and accuracy of 100%
- Broad CoverageFirst clinical testing product based on high-throughput sequencing technology to achieve comprehensive screening of embryonic chromosomes
- High resolutionCan detect chromosomal deletions or duplications of ≥4Mb and known chromosomal deletions or duplications of ≥1Mb

Pre-Implantation Single Gene Genetic Disease Detection Reagent Kit
Basecare Medical's production of the 'Pre-Implantation Single Gene Genetic Disease Detection Reagent Kit' is the first product to use an artificial intelligence system for feasibility assessment. It can effectively predict the success rate of constructing the monotype linkage analysis of the gene family. This product does not require pre-experimental design of primers for different genetic diseases and can detect over 4,000 single gene genetic diseases, achieving a breakthrough from customized to universal products. This product is suitable for confirmed pathogenic mutations, effectively avoiding the generational transmission of genetic diseases.
- Wide ApplicabilityA universal detection reagent kit that does not require primer design is suitable for over 4,000 single gene genetic diseases
- Simple ProcessNo pre-experiment is required, embryos and family samples are tested simultaneously, shortening the reporting cycle
- Comprehensive DetectionSimultaneous Analysis of Single Gene Genetic Diseases, Chromosome Number, and Structural Abnormalities
- Strict Quality ControlSimultaneous detection of whole-genome monotype linkage analysis and variant sites for double verification to ensure result accuracy

Pre-Implantation Chromosome Structural Abnormality Detection Reagent Kit
Basecare Medical's production of the 'Pre-Implantation Chromosome Structural Abnormality Detection Reagent Kit' is based on the single nucleotide polymorphism (SNP) markers across the entire genome for monotype linkage analysis, clarifying the monotype of normal and structurally abnormal chromosomes, ultimately achieving accurate identification of embryos carrying the full genome of 23 pairs of chromosomes, and effectively preventing the vertical transmission of chromosomal abnormalities, thereby reducing the risk of miscarriage. This method is a universal solution that does not require the design of special primers for different translocation families.
- Comprehensive DetectionCan analyze chromosomal aneuploidy, chromosomal structural abnormalities, triploidy, and regions of homozygosity (ROH) across the entire genome
- High Success RateHigher success rate in constructing monotype linkage analysis covering the entire genome
- Risk WarningAnalysis of monotype linkage throughout the entire genome, warning of the risk of homologous recombination
- Simple and EfficientNo need for separate primer design for different translocation families



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