PGT laboratory_贝康医疗
B A S E C A R E
Genetics Laboratory
Product Scenarios

Genetics Laboratory

The genetic laboratory is an assessment requirement for third-generation test tube qualification applications, and the laboratory needs to be equipped with high-throughput sequencers, automated workstations, PCR analyzers, PGT and genetic testing reagent kits, etc. Large-scale clinical trials show that PGT-A can increase the clinical pregnancy rate to 72%, and reduce the miscarriage rate to 6.9%. Basecare Medical participated in the drafting of quality control technical evaluation guidelines for PGT-A detection reagents, and the developed PGT-A reagent kit obtained the first 'Special Approval for Innovative Medical Devices' for Class III medical devices, filling the clinical gap of genetic testing reagent kits for third-generation test tube babies in China. PGT-M and PGT-SR reagent kits can be used to block the transmission of genetic diseases to the next generation. In addition, Basecare Medical's domestically produced high-throughput sequencer DA500 has obtained the national Class III medical device registration certificate.

Main Equipment

DA8600 Gene Sequencer

The DA8600 semiconductor gene sequencer is a new generation high-throughput sequencer developed and produced by Sun Yat-sen University Da An Gene Co., Ltd., specifically for clinical applications. It is also the first domestically approved medical device registration certificate issued by the National Medical Products Administration, Registration No. 20143221961.of the semiconductor gene sequencer. Currently, Basecare Medical has obtained the exclusive authorization for the DA8600 semiconductor gene sequencer in the field of assisted reproduction, and is fully responsible for the sales and after-sales service of the equipment in the field of assisted reproduction.language_492

  • Fast Speed
    Completes a genetic test in just 2-3 hours, significantly improving detection efficiency
  • Long Sequencing Reads
    Average sequencing read length of 200bp ensures data accuracy and reliability
  • Moderate Throughput
    Can simultaneously sequence multiple projects, balancing clinical testing costs and reporting cycles
  • Widespread Application
    Approved for Class III reagent kits in non-invasive prenatal, tumor, and reproductive fields

DA500 High-Throughput Sequencer

DA500 High-Throughput Sequencer (National Medical Device Registration 20233221281) is a compact, flexible desktop single-slide gene sequencing platform that provides users with flexible and efficient sequencing choices. The sequencer adopts excellent biochemical and optical systems, supports two different chip specifications, and can generate sequencing data volumes ranging from 10Gb to 150Gb in a single run. It also has stable high-intensity signals and a low sequencing error rate, meeting the needs of customers for sequencing throughput and efficiency in different scenarios.

  • Flexible Sequencing Throughput
    Supports two different chip specifications, with sequencing data volumes ranging from 10Gb to 150Gb
  • High Accuracy
    Uses rolling circle replication amplification technology and carries a regular array slide to improve sequencing accuracy
  • High Compatibility with Detection Projects
    Applicable to pre-pregnancy, prenatal, pre-implantation, and newborn screening throughout the entire reproductive cycle
  • Low Operating Costs
    Can meet the requirements for sequencing throughput and efficiency in different scenarios

BS1000C Automated Sample Preparation System

The BS1000C high-throughput automated sample preparation system is a compact, feature-rich, and flexible desktop multifunctional automated workstation. It can help you automate most library construction processes. The workstation is equipped with a 96-channel pipettor, built-in routine high-throughput sequencing library construction processes, and nucleic acid extraction processes. It is designed for fully automated operations and can achieve long periods of unattended operation. It can also be customized according to customer needs, making it an efficient, flexible, and widely applicable automated sample preparation system.

  • Fully Automated
    Integrates multiple instruments and equipment for fully automated library construction and other experimental operations
  • Flexible and Reliable
    Switch between 8 to 96 channels flexibly, with 20 modules in various combinations, customizable based on requirements
  • Easy Operation
    Automated library construction with graphical user guidance, intuitive and quick to operate, less prone to errors
  • Safe and Stable
    Equipped with UV lamp and efficient filter, reduces aerosol contamination risk, ensuring personnel safety

Main Reagents

Pre-Implantation Chromosome Aneuploidy Detection Reagent Kit (Semiconductor Sequencing Method)

Basecare Medical's production of the 'Pre-Implantation Chromosome Aneuploidy Detection Reagent Kit (Semiconductor Sequencing Method)' is the first PGT-A detection reagent kit approved for marketing by the National Medical Products Administration (NMPA) in China (National Medical Device Registration 20203400181). The reagent kit is based on high-throughput sequencing technology, qualitatively detecting the DNA of embryonic trophectoderm cells during the in vitro fertilization process, analyzing whether the embryo's chromosomes have aneuploidy abnormalities, and assisting clinical doctors in determining whether the embryo is suitable for implantation.
National Certification

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    High Precision
  • Covers a Wide Range
    Detects chromosomal aneuploidy with a sensitivity, specificity, and accuracy of 100%
  • Broad Coverage
    First clinical testing product based on high-throughput sequencing technology to achieve comprehensive screening of embryonic chromosomes
  • High resolution
    Can detect chromosomal deletions or duplications of ≥4Mb and known chromosomal deletions or duplications of ≥1Mb

Pre-Implantation Single Gene Genetic Disease Detection Reagent Kit

Basecare Medical's production of the 'Pre-Implantation Single Gene Genetic Disease Detection Reagent Kit' is the first product to use an artificial intelligence system for feasibility assessment. It can effectively predict the success rate of constructing the monotype linkage analysis of the gene family. This product does not require pre-experimental design of primers for different genetic diseases and can detect over 4,000 single gene genetic diseases, achieving a breakthrough from customized to universal products. This product is suitable for confirmed pathogenic mutations, effectively avoiding the generational transmission of genetic diseases.

  • Wide Applicability
    A universal detection reagent kit that does not require primer design is suitable for over 4,000 single gene genetic diseases
  • Simple Process
    No pre-experiment is required, embryos and family samples are tested simultaneously, shortening the reporting cycle
  • Comprehensive Detection
    Simultaneous Analysis of Single Gene Genetic Diseases, Chromosome Number, and Structural Abnormalities
  • Strict Quality Control
    Simultaneous detection of whole-genome monotype linkage analysis and variant sites for double verification to ensure result accuracy

Pre-Implantation Chromosome Structural Abnormality Detection Reagent Kit

Basecare Medical's production of the 'Pre-Implantation Chromosome Structural Abnormality Detection Reagent Kit' is based on the single nucleotide polymorphism (SNP) markers across the entire genome for monotype linkage analysis, clarifying the monotype of normal and structurally abnormal chromosomes, ultimately achieving accurate identification of embryos carrying the full genome of 23 pairs of chromosomes, and effectively preventing the vertical transmission of chromosomal abnormalities, thereby reducing the risk of miscarriage. This method is a universal solution that does not require the design of special primers for different translocation families.

  • Comprehensive Detection
    Can analyze chromosomal aneuploidy, chromosomal structural abnormalities, triploidy, and regions of homozygosity (ROH) across the entire genome
  • High Success Rate
    Higher success rate in constructing monotype linkage analysis covering the entire genome
  • Risk Warning
    Analysis of monotype linkage throughout the entire genome, warning of the risk of homologous recombination
  • Simple and Efficient
    No need for separate primer design for different translocation families
Free lab Design